Almost before the ink was dry, the state’s largest nursery is protesting a rule floated by health regulators setting up the framework for Florida’s new medical-marijuana industry.

Miami-based Costa Farms filed a challenge Monday in the state Division of Administrative Hearings, questioning the proposed use of a lottery to pick five licensees—one in each region of the state—to grow, process and distribute the non-euphoric strains of cannabis legalized by the Legislature and Gov. Rick Scott this spring.