Former friends working on a venture meant to transform Miami’s Wynwood neighborhood, the largest landowner and one of the area’s prominent real estate brokers are no longer on speaking terms, locked instead in a legal fight over a key parcel.

Moishe Mana, an Israeli entrepreneur with plans to turn 25 acres between Northwest Second Avenue and Northwest Sixth Avenue into an arts-focused complex, is suing Tony Cho, a broker whose Metro 1 Properties Inc. has arranged the bulk of Mana’s Wynwood acquisitions since 2009.